Friday, February 26, 2010


These material are neither obtained from USMLE database nor obtained from people who took the test before. These are just studying notes that have been used by many applicants who passed the exam and scored 99 (>250 on triple digit score). I hope it will benefit you too. Please click on the follow button to keep tract of our site when you need to revise from the notes later.

Before starting with the USMLE Step 1 notes I just want to tell you 4 important things you need to keep in mind:

1-The notes are divided into 21 groups, in this page you will find the first group and on the other twenty pages posted at the top of this page you will find the remainder of the groups.

2-On the left sidebar of this group you will find the links to the IMG friendly residency programs lists in all specialties. If you don't use these lists when you apply to residency it is less likely that you will get interviews.

3-Also on the left side of this page you will find the link to the observerships, electives and externships list which contains all the programs in the US that offer IMGs by USCE. Almost all IMGs use this list, get it soon and start contacting the programs mentioned in it to secure your spot in the desired time.


Group 1

1• Subendothelial Deposits are seen in SLE patients

2• Subepithelial Humps are seen in Acute Poststreptococcal Glomeruloneprhitis

3• Linear Subendothelial are seen in Goodpasture’s (Type II)

4• Mesangial Deposits are seen in IgA Nephropathy

5• Spike and Dome are seen in Membranous

6• Subendothelial Humps are seen in Membranoproliferative

7• Azithromycin – administered to HIV + patients can prevent Mycobacterium Avium

8• Ethambutol – inhibits arabinosyl transferase which polymerizes arabinose into arabinan etc. Side Effects à Optic Neuritis

9• Rifampin – inhibits bacterial DNA dependent RNA polymerase and thus prevents transcription of DNA into mRNA.

10• Isoniazid – inhibits mycolic acid synthesis.

11• FF = GFR/RPF

12•GFR = Creatinine Clearance/Inulin

13• RPF = PAH

14• Fibroadenoma – cellular myxoid stroma, sometimes there are compressed cystic spaces.

15• Spongiosis - epidermal accumulation of edematous fluid in the intercellular spaces.

16• Diphenoxylate – opiate anti-diarrheal structurally related to Meperidine.

17• Octreotide – good for secretory diarrhea, which is a Somatostatin Analog

18• Urease – converts urea to carbon dioxide and ammonia and thus increases pH

19• Radiation Therapy - causes 1) DNA double strand breakage 2) formation of free radical

20• Methadone – has a long half life

21• In Fetal Lungs - after 30 weeks there is an increase in Lecithin

22• After 36 weeks there is a rise in Phosphatydylglycerol

23• Males with 5 α reductase deficiency - feminized external genitalia, small phallus and Hypospadias are common.

24• Repair Damage – Glycosylase à Endonuclease à Lyase à DNA Polymerase à Ligase

25• H. Pylori – most common cause of duodenal ulcers

26• CMV in immunocompromised – Mononucleosis

27• Retinitis in CMV – HIV+ Patients

28• Primary CNS Lymphoma – most commonly associated with AIDS

29• Squamous Cell Lung Cancer – produces Parathyroid Hormone Related Peptide, which in turn will decrease PTH

30• Campylobacter – can be transmitted from domestic animals

31• Shigella - is transmitted via fecal oral in day care centers

32• Keratin - marker of epithelial cell origin.

33• Secretin - produced by S endocrine cells in the duodenum, that increases bicarbonate secretion from exocrine pancreas into the small bowel.

34• Alprazolam – benzodiazepine with the shortest half life, which is used in Acute Anxiety.

35• Diazepam, Chlordiazepoxide and Clonazepam – longest half life, used in prophylaxis.

36• Sheets of Primitive Cells with Many Mitotic Figures – Medulloblastoma

37• Most Common Tumors in Children:

38• Pilocytic Astrocytoma - Rosenthal Fibers

39• Medulloblastoma - sheets of small blue cells, many mitotic figures

40• Ependyoma – can cause Hydrocephalus and form Rosettes